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DeCS
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Descriptor English:
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Complement Pathway, Classical
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Descriptor Spanish:
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vía clásica del complemento
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Descriptor Portuguese:
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Via Clássica do Complemento
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Synonyms English:
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Classical Complement Activation Pathway
Classical Complement Pathway
Complement Activation Pathway, Classical
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Tree Number:
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G12.274.698
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Definition English:
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Complement activation initiated by the binding of COMPLEMENT C1 to ANTIGEN-ANTIBODY COMPLEXES at the COMPLEMENT C1Q subunit. This leads to the sequential activation of COMPLEMENT C1R and COMPLEMENT C1S subunits. Activated C1s cleaves COMPLEMENT C4 and COMPLEMENT C2 forming the membrane-bound classical C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and the assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX. |
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History Note English:
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91(79); was see under COMPLEMENT ACTIVATION 1979-90
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Allowable Qualifiers English:
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Record Number:
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3217
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Unique Identifier:
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D003171
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Occurrence in VHL:
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Similar:
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DeCS
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